| Dr. David J. Lynn (M.Sc., Ph.D.) |
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| Position: |
Vision Appointment in Computational Biology |
| Role: |
Computational/Systems Biologist
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| Location: |
Animal Bioscience Centre,
Grange,
Dunsany,
Co. Meath
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| Research Interests: |
Systems Biology
Bioinformatics
Innate Immunity
Infectious Disease
Population Genetics/Evolution
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| Current Projects: |
InnateDB (www.innatedb.com) a systems biology platform for the analysis of mammalian signalling.
Enabling bovine systems biology in the post-genomics era.
Systems biology approaches to whole-genome selection technology (milk production/ mastitis).
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| Selected publications (2006-2009): |
Gardy J.L., Lynn D.J.*, Brinkman F.S.L., Hancock R.E.W. (2009). Enabling a systems biology approach to immunology: focus on innate immunity. Trends in Immunology 30(6), 249-262. *Joint First Author.
The Bovine Genome Sequencing and Analysis Consortium* (2009). The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science 324(5926), 522-528. *Analysis Project Leader.
The Bovine HapMap Consortium (2009). Genome Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds. Science 324(5926), 528-532.
Downing T., Lynn D.J., Connell S., Lloyd A.T., Bhuiyan A.K.F.H., Silva P., Naqvi A., Sanfo R., Sow R.S., Podisi B., O’Farrelly C., Hanotte O., Bradley D.G. (2009). Contrasting Evolution of Diversity at Two Disease-Associated Chicken Genes. Immunogenetics 61(4), 303-314.
Lemay D.G., Lynn D.J., Martin W.F., Casey T.M., Kriventseva E.V., Rincon G., Barris W., Hinrichs A.S., Molenaar A.J., Pollard K.S., Neville M.C., Maqbool N.J., Zdobnov E.M., Medrano J.F., Tellam R., German J.B., Rijnkels M. (2009). The Bovine Lactation Genome: Insights into the Evolution of Mammalian Milk. Genome Biology 10(4):R43.
Lynn D.J.*, Winsor G.L., Chan C., Richard N., Laird M.R., Barsky A., Gardy J.L., Roche F.M., Chan T.H.W., Shah N., Lo R., Naseer M., Que J., Yau M., Acab M., Tulpan D., Whiteside M.D., Chikatamarla A., Mah B., Munzner T., Hokamp K., Hancock R.E.W., Brinkman F.S.L. (2008). InnateDB - Facilitating Systems Level Analyzes of the Mammalian Innate Immune Response. Molecular Systems Biology 4:218 (www.nature.com/msb). *Joint Corresponding Author.
Freeman A.R.*, Lynn D.J.*, Murray C., Bradley D.G. (2008). Detecting the Effects of Selection at the Population Level in Bovine Immune Genes. BMC Genetics 9:62. * Joint First Author
Lynn D.J., Higgs R., Lloyd A.T., Hervé-Grépinet V., Nys Y., Brinkman F.S.L., Yu P.L., Soulier A., Kaiser P., Zhang G., O’Farrelly C., Lehrer R.I. (2007). Avian Beta-Defensin Nomenclature: A Community Proposed Update. Immunology Letters 110(1), 86-89. *Corresponding Author.
Lynn D.J.*, Bradley, D.G. (2007). Discovery of alpha-Defensins in Basal Mammals. Developmental & Comparative Immunology 31(10), 963-967 * Corresponding Author.
See www.pathogenomics.ca/~dlynn for all publications
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| Collaborations and contacts: |
Prof. Fiona Brinkman: Simon Fraser University, Vancouver, Canada. Systems biology of innate immunity.
Prof. Bob Hancock: University of British Columbia, Vancouver, Canada. Systems biology of innate immunity.
Prof. Dan Bradley: Trinity College Dublin, Dublin, Ireland. Population Genomics Approaches to Detecting Selection in the Bovine and Chicken Genomes.
Dr. Philip Cooper: St. Georges Hospital, London, UK. Analysis of the Host Response to Helminth Infections in Ecuadorian Children.
Prof. Gordon Dougan; Fernanda Schreiber: Wellcome Trust Sanger Institute, Hinxton, UK. Systems Biology Analyses of Human Infections.
Prof. Christine Elsik & International Bovine Genome Consortium: Georgetown University, Washington DC, USA. Adaptive Evolution in the Bovine Genome.
Dr. Martin Ester: Simon Fraser University, Vancouver, Canada. Developing Novel Network Analysis Algorithms.
Melita Gordon: University of Liverpool, Liverpool, UK. Pathway and Network Analysis of NTS in HIV+ Patients in Malawi.
Prof. Bill Jacobs, Dr. Dee Dao: Albert Einstein College of Medicine, New York, USA. Analysis of the Host Response to TB in a Murine Model.
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| Conferences attended (2007-2009): |
Enabling Bovine Systems Biology in the Post-Genomics Era. Bovine Genome and HapMap Consortia Meeting. Cold Spring Harbor, New York. 11th May 2009.
InnateDB & Meta-analysis – Pathways, Networks & Hubs – Targets for Modulation. Grand Challenges in Global Health Project Meeting, Bangkok, Thailand. Oct. 23rd 2008.
InnateDB – Facilitating Systems Level Analyses of the Mammalian Innate Immune System. Vancouver Bioinformatics User Group Seminar, BC Cancer Research Centre, Vancouver, B.C., Canada. 11th Sept. 2008.
InnateDB – Facilitating Systems Level Analyses of the Mammalian Innate Immune System. Grand Challenges in Global Health Project Meeting, Paris, France. 8-10th Jan. 2008. [Invited speaker].
InnateDB – Facilitating Systems Level Analyses of the Mammalian Innate Immune System. Departmental Seminar, School of Biochemistry and Immunology, Trinity College Dublin, Ireland. 20th Dec. 2007.
InnateDB - A Knowledge Base for Systems Biology Approaches to Studying Mammalian Innate Immunity. 3rd Annual Grand Challenges in Global Health Meeting, Cape Town, South Africa. 6-9th Oct. 2007.
Bioinformatics Approaches Aiding Comparative and Functional Genomics - 57th Annual Meeting of the Canadian Society of Microbiologists. University Laval, Quebec City, Quebec, Canada. 18th June 2007
Detecting Selection in the Bovine and Chicken Genomes. Seminar at the International Livestock Research Institute, Nairobi, Kenya. 23rd Nov. 2005.
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| Telephone: |
+1 778 782 2061 (SFU, Canada) |
| Email: |
david.lynn@teagasc.ie |
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